Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.

{"article_title":"Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS\/CDC\/ERS\/IDSA Clinical Practice Guideline.","author":"\"Saukkonen, Jussi J , Duarte, Raquel , Munsiff, Sonal S , Winston, Carla A , Mammen\"","journal_title":"American journal of respiratory and critical care medicine","issn":"1535-4970 ; Electronic","isbn":"","publication_date":"20250101","volume":"211","issue":"1","first_page":"15","page_count":"19","accession_number":"40693952","doi":"10.1164\/rccm.202410-2096ST","publisher":"American Thoracic Society","doctype":"Journal Article; Practice Guideline","subjects":"Pulmonary ","interest_area":["Infectious Disease & Vaccines"," Pulmonology"],"abstract":"<b>Background:<\/b> On the basis of recent clinical trial data for the treatment of drug-susceptible and drug-resistant tuberculosis (TB), the American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America have updated clinical practice guidelines for TB treatment in children and adults in settings in which mycobacterial cultures, molecular and phenotypic drug susceptibility tests, and radiographic studies, among other diagnostic tools, are available on a routine basis. <b>Methods:<\/b> A Joint Panel representing multiple interdisciplinary perspectives convened with American Thoracic Society methodologists to review evidence and make recommendations using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and GRADE-ADOLOPMENT (adoption, adaptation, and, as needed, <i>de novo<\/i> development of recommendations) methodology. <b>Results:<\/b> New drug-susceptible TB recommendations include the use of a novel 4-month regimen for people with pulmonary TB and a shortened 4-month regimen for children with nonsevere TB. Drug-resistant TB recommendation updates include the use of novel regimens containing bedaquiline, pretomanid, and linezolid with or without moxifloxacin. <b>Conclusions:<\/b> All-oral, shorter treatment regimens for TB are now recommended for use in eligible individuals.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=40693952&authtype=shib&custid=ns346513","isPdfLink":true,"isSAML":false,"additionalInfo":{"Authored_By":"Saukkonen JJ, Duarte R, Munsiff SS, Winston CA, Mammen MJ, Abubakar I, Acu\u00f1a-Villaordu\u00f1a C, Barry PM, Bastos ML, Carr W, Chami H, Chen LL, Chorba T, Daley CL, Garcia-Prats AJ, Holland K, Konstantinidis I, Lipman M, Battista Migliori G, Parvez FM, Shapiro AE, Sotgiu G, Starke JR, Starks AM, Thakore S, Wang SH, Wortham JM, Nahid P","Journal_Info":"Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE","Publication_Type":"Journal Article; Practice Guideline","Published_Date":"2025-01-01","Source":"American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2025 Jan; Vol. 211 (1), pp. 15-33.","Languages":"English","Electronic_ISSN":"1535-4970","MeSH_Terms":"Antitubercular Agents*\/therapeutic use , Antitubercular Agents*\/administration & dosage , Tuberculosis, Multidrug-Resistant*\/drug therapy , Tuberculosis, Pulmonary*\/drug therapy, Humans ; Child ; United States ; Adult ; Mycobacterium tuberculosis\/drug effects ; Diarylquinolines\/therapeutic use ; Centers for Disease Control and Prevention, U.S. ; Drug Therapy, Combination","Subjects":"Humans, Child, United States, Adult, Mycobacterium tuberculosis drug effects, Diarylquinolines therapeutic use, Centers for Disease Control and Prevention, U.S., Drug Therapy, Combination, Antitubercular Agents therapeutic use, Antitubercular Agents administration & dosage, Tuberculosis, Multidrug-Resistant drug therapy, Tuberculosis, Pulmonary drug therapy","Title_Abbreviations":"American journal of respiratory and critical care medicine","Volume":"211"},"header":{"DbId":"mdl","DbLabel":"MEDLINE Ultimate","An":"40693952","RelevancyScore":"949","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"948.988342285156"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=40693952&authtype=shib&custid=ns346513&group=main&profile=eds","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=40693952&authtype=shib&custid=ns346513&group=main&profile=eds"}