[S3 guidelines on diagnostics and treatment of cervical cancer: Demands on pathology].

{"article_title":"[S3 guidelines on diagnostics and treatment of cervical cancer: Demands on pathology].","author":"Horn LC, Beckmann MW, Follmann M, Koch MC, Mallmann P, Marnitz S, Schmidt D","journal_title":"Der Pathologe","issn":"1432-1963","isbn":"","publication_date":"2019 Oct","volume":"36","issue":"6","first_page":"585","page_count":"","accession_number":"26483249","doi":"10.1007\/s00292-015-0114-z","publisher":"Springer-Verlag","doctype":"Consensus Development Conference","subjects":"Germany; Uterine Cervical Neoplasms diagnosis; Uterine Cervical Neoplasms pathology; Uterine Cervical Neoplasms therapy; Cervix Uteri pathology; Cooperative Behavior; Female; Germany; Humans; Interdisciplinary Communication; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; World Health Organization","interest_area":["Obstetrics & Gynecology"," Oncology"," Internal Medicine"],"abstract":"Between 2011 and the end of 2014 the former consensus S2k guidelines for the diagnostics and treatment of cervical cancer were updated and upgraded to S3 level, methodologically based on the regulations of the German Cancer Society (DKG). The present article summarizes the relevant aspects for the sectioning, histopathological workup, diagnostics and reporting for the pathology of invasive cancer of the uterine cervix. The recommendations are based on the most recent World Health Organization (WHO) and TNM classification systems and consider the needs of the clinician for appropriate surgical and radiotherapeutic treatment of patients. Detailed processing rules of colposcopy-guided diagnostic biopsies, conization and trachelectomy as well as for radical hysterectomy specimens and lymph node resection (including sentinel lymph node resection) are given. In the guidelines deep stromal invasion in macroinvasive cervical cancer is defined for the first time as tumor infiltration of > 66% of the cervical stromal wall. Furthermore, morphological prognostic factors for microinvasive and macroinvasive cervical cancer are summarized.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=26483249&authtype=shib&custid=ns346513&group=main&profile=eds","isPdfLink":true,"isSAML":false,"additionalInfo":{"Authored_By":"Horn LC, Beckmann MW, Follmann M, Koch MC, Mallmann P, Marnitz S, Schmidt D","Corporate_Authors":"German Cancer Society (DKG)","Journal_Info":"Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 8006541 Publication Model: Print Cited Medium: Internet ISSN: 1432-1963 (Electronic) Linking ISSN: 01728113 NLM ISO Abbreviation: Pathologe Subsets: MEDLINE","Publication_Type":"Consensus Development Conference; English Abstract; Journal Article; Practice Guideline","Published_Date":"2015-11-01","Source":"Der Pathologe [Pathologe] 2015 Nov; Vol. 36 (6), pp. 585-93.","Languages":"German","Electronic_ISSN":"1432-1963","MeSH_Terms":"Uterine Cervical Neoplasms\/*diagnosis , Uterine Cervical Neoplasms\/*pathology , Uterine Cervical Neoplasms\/*therapy, Cervix Uteri\/pathology ; Cooperative Behavior ; Female ; Germany ; Humans ; Interdisciplinary Communication ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; World Health Organization","Subjects":"Cervix Uteri pathology, Cooperative Behavior, Female, Germany, Humans, Interdisciplinary Communication, Neoplasm Invasiveness, Neoplasm Staging, Prognosis, World Health Organization, Uterine Cervical Neoplasms diagnosis, Uterine Cervical Neoplasms pathology, Uterine Cervical Neoplasms therapy","Title_Abbreviations":"Der Pathologe","Volume":"36"},"header":{"DbId":"mdl","DbLabel":"MEDLINE Ultimate","An":"26483249","RelevancyScore":"802","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"802.353210449219"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=26483249&authtype=shib&custid=ns346513&group=main&profile=eds","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=26483249&authtype=shib&custid=ns346513&group=main&profile=eds"}