[Recommendations for the treatment of AL amyloidosis].

{"article_title":"[Recommendations for the treatment of AL amyloidosis].","author":"Brulc EB, Carretero M, Aguirre MA, Negro A, Ulacia MD, Perez de Arenaza D, Villanueva E, S\u00e1ez MS, Sorroche P, Posadas Mart\u00ednez ML, Nucifora EM","journal_title":"Medicina","issn":"1669-9106","isbn":"","publication_date":"2020","volume":"82","issue":"4","first_page":"591","page_count":"","accession_number":"35904916","doi":"","publisher":"Fundacio\u0301n Revista Medicina (Buenos Aires)","doctype":"Practice Guideline","subjects":"Amyloidosis therapy; Hematopoietic Stem Cell Transplantation adverse effects; Immunoglobulin Light-chain Amyloidosis etiology; Immunoglobulin Light-chain Amyloidosis therapy; Bortezomib therapeutic use; Humans; Melphalan therapeutic use; Transplantation, Autologous; Treatment Outcome","interest_area":["Immunology Allergy & Inflammation"," Internal Medicine"],"abstract":"Introduction: Immunoglobulin light chain (AL) amyloidosis is a rare disease. Treatment is challenging, justified in part by systemic compromise and limited scientific evidence. Objectives: Develop evidencebased recommendations that allow adequate treatment of patients with amyloidosis AL. Methods: A list of PICO format questions focused on the effectiveness and safety of amyloidosis AL treatment was generated. PubMed, Cochrane and Epistemonikos were searched. The levels of evidence and grades of recommendation were based on the GRADE system. Results: 11 recommendations were generated. In selected patients with amyloidosis AL, autologous hematopoietic stem cell transplantation (ASCT) is recommended after induction with bortezomibbased regimens and conditioning with melphalan, since it could deepen the hematological and organ response, its durability and improve survival. In patients not eligible for ASCT, first-line treatment with bortezomib-based regimens is recommended, since it is likely to achieve a higher rate of hematological and organ response and improve survival. In patients with a contraindication or inaccessibility to bortezomib, treatment with alkylating agents and corticosteroids is recommended, since they are likely to achieve haematological and organ response and improve survival. Discussion: These treatment recommendations are based on the available evidence and the experience of the panel of experts, in a scenario of limited available resources, according to developing countries.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=35904916&authtype=shib&custid=ns346513&group=main&profile=eds","isPdfLink":true,"isSAML":false,"additionalInfo":{"Authored_By":"Brulc EB, Carretero M, Aguirre MA, Negro A, Ulacia MD, Perez de Arenaza D, Villanueva E, S\u00e1ez MS, Sorroche P, Posadas Mart\u00ednez ML, Nucifora EM","Journal_Info":"Publisher: Fundacio\u0301n Revista Medicina (Buenos Aires) Country of Publication: Argentina NLM ID: 0204271 Publication Model: Print Cited Medium: Internet ISSN: 1669-9106 (Electronic) Linking ISSN: 00257680 NLM ISO Abbreviation: Medicina (B Aires) Subsets: MEDLINE","Publication_Type":"Practice Guideline; Journal Article","Published_Date":"2022-01-01","Source":"Medicina [Medicina (B Aires)] 2022; Vol. 82 (4), pp. 591-604.","Languages":"Spanish; Castilian","Electronic_ISSN":"1669-9106","MeSH_Terms":"Amyloidosis*\/therapy , Hematopoietic Stem Cell Transplantation*\/adverse effects , Immunoglobulin Light-chain Amyloidosis*\/etiology , Immunoglobulin Light-chain Amyloidosis*\/therapy, Bortezomib\/therapeutic use ; Humans ; Melphalan\/therapeutic use ; Transplantation, Autologous ; Treatment Outcome","Subjects":"Bortezomib therapeutic use, Humans, Melphalan therapeutic use, Transplantation, Autologous, Treatment Outcome, Amyloidosis therapy, Hematopoietic Stem Cell Transplantation adverse effects, Immunoglobulin Light-chain Amyloidosis etiology, Immunoglobulin Light-chain Amyloidosis therapy","Title_Abbreviations":"Medicina","Volume":"82"},"header":{"DbId":"mdl","DbLabel":"MEDLINE Ultimate","An":"35904916","RelevancyScore":"907","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"906.698547363281"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=35904916&authtype=shib&custid=ns346513&group=main&profile=eds","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=35904916&authtype=shib&custid=ns346513&group=main&profile=eds"}