Risk of early- and late-onset Alzheimer disease and related dementia in adults with cerebral palsy.

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Clinical Guidelines
Authored By
Mahmoudi E, Lin P, Kamdar N, Gonzales G, Norcott A, Peterson MD
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Interests
Neurology
Speciality
Neurology
Book Detail
volume
64
ISSN
1469-8749
No. of pages
7
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ISSN
1469-8749 ; Electronic
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true
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["Mahmoudi E, Lin P, Kamdar N, Gonzales G, Norcott A, Peterson MD","Publisher: Blackwell Country of Publication: England NLM ID: 0006761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8749 (Electronic) Linking ISSN: 00121622 NLM ISO Abbreviation: Dev Med Child Neurol Subsets: MEDLINE","Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.","2022-03-01","Developmental medicine and child neurology [Dev Med Child Neurol] 2022 Mar; Vol. 64 (3), pp. 372-378. Date of Electronic Publication: 2021 Sep 08.","English","1469-8749","Cerebral Palsy\/*epidemiology , Dementia\/*epidemiology, Aged ; Alzheimer Disease\/epidemiology ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; United States\/epidemiology","Aged, Alzheimer Disease epidemiology, Comorbidity, Female, Humans, Male, Middle Aged, Proportional Hazards Models, United States epidemiology, Cerebral Palsy epidemiology, Dementia epidemiology","Developmental medicine and child neurology","64"]
Description
Aim: To examine the risk of Alzheimer disease and related dementia (ADRD) among adults with cerebral palsy (CP).<br />Method: Using administrative insurance claims data for 2007 to 2017 in the USA, we identified adults (45y or older) with a diagnosis of CP (n=5176). Adults without a diagnosis of CP were included as a typically developing comparison group (n=1 119 131). Using age, sex, ethnicity, other demographic variables, and a set of chronic morbidities, we propensity-matched individuals with and without CP (n=5038). Cox survival models were used to estimate ADRD risk within a 3-year follow up.<br />Results: The unadjusted incidence of ADRD was 9 and 2.4 times higher among cohorts of adults 45 to 64 years (1.8%) and 65 years and older (4.8%) with CP than the respective unmatched individuals without CP (0.2% and 2.0% among 45-64y and 65y or older respectively). Fully adjusted survival models indicated that adults with CP had a greater hazard for ADRD (among 45-64y: unmatched hazard ratio 7.48 [95% confidence interval {CI} 6.05-9.25], matched hazard ratio 4.73 [95% CI 2.72-8.29]; among 65y or older: unmatched hazard ratio 2.21 [95% CI 1.95-2.51], matched hazard ratio 1.73 [1.39-2.15]).<br />Interpretation: Clinical guidelines for early screening of cognitive function among individuals with CP need updating, and preventative and/or therapeutic services should be used to reduce the risk of ADRD.<br /> (© 2021 Mac Keith Press.)
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