Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline.

Select Content Type
Clinical Guidelines
Authored By
Møller MH, Alhazzani W, Lewis K, Belley-Cote E, Granholm A, Centofanti J, McIntyre WB, Spence J, Al Duhailib Z, Needham DM, Evans L, Reintam Blaser A, Pisani MA, D'Aragon F, Shankar-Hari M, Alshahrani
Authored On
Interests
Emergency Medicine
Pulmonology
Speciality
Emergency Medicine
Pulmonology
Book Detail
volume
48
ISSN
1432-1238
No. of pages
10
Publication Date
Actions
Download in App
Event Data
{"article_title":"Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline.","author":"\"M\u00f8ller, Morten H , Alhazzani, Waleed , Lewis, Marlies\"","journal_title":"Intensive care medicine","issn":"1432-1238 ; Electronic","isbn":"","publication_date":"20220701","volume":"48","issue":"7","first_page":"801","page_count":"10","accession_number":"35587274","doi":"10.1007\/s00134-022-06660-x","publisher":"Springer Verlag","doctype":"Journal Article","subjects":"Anesthisia","interest_area":["Emergency Medicine"," Pulmonology"],"abstract":"The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM\u2011RPG) was to formulate evidence\u2011based guidance for the use of dexmedetomidine for sedation in invasively mechanically ventilated adults in the intensive care unit (ICU).","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=35587274&authtype=shib&custid=ns346513","isPdfLink":true,"isSAML":false,"additionalInfo":{"Authored_By":"M\u00f8ller MH, Alhazzani W, Lewis K, Belley-Cote E, Granholm A, Centofanti J, McIntyre WB, Spence J, Al Duhailib Z, Needham DM, Evans L, Reintam Blaser A, Pisani MA, D'Aragon F, Shankar-Hari M, Alshahrani M, Citerio G, Arora RC, Mehta S, Girard TD, Ranzani OT, Hammond N, Devlin JW, Shehabi Y, Pandharipande P, Ostermann M","Journal_Info":"Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE","Publication_Type":"Journal Article","Published_Date":"2022-07-01","Source":"Intensive care medicine [Intensive Care Med] 2022 Jul; Vol. 48 (7), pp. 801-810. Date of Electronic Publication: 2022 May 19.","Languages":"English","Electronic_ISSN":"1432-1238","MeSH_Terms":"Anesthesia* , Dexmedetomidine*\/therapeutic use, Adult ; Humans ; Hypnotics and Sedatives\/therapeutic use ; Intensive Care Units ; Respiration, Artificial\/methods","Subjects":"Adult, Humans, Hypnotics and Sedatives therapeutic use, Intensive Care Units, Respiration, Artificial methods, Anesthesia, Dexmedetomidine therapeutic use","Title_Abbreviations":"Intensive care medicine","Volume":"48"},"header":{"DbId":"mdl","DbLabel":"MEDLINE Ultimate","An":"35587274","RelevancyScore":"865","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"865.021240234375"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=35587274&authtype=shib&custid=ns346513&group=main&profile=eds","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=35587274&authtype=shib&custid=ns346513&group=main&profile=eds"}
ISSN
1432-1238 ; Electronic
IS_Ebsco
true
Upload Link
https://search.ebscohost.com/login.aspx?direct=true&db=mdl&AN=35587274&authtype=shib&custid=ns346513
Additional Info
["M\u00f8ller MH, Alhazzani W, Lewis K, Belley-Cote E, Granholm A, Centofanti J, McIntyre WB, Spence J, Al Duhailib Z, Needham DM, Evans L, Reintam Blaser A, Pisani MA, D'Aragon F, Shankar-Hari M, Alshahrani M, Citerio G, Arora RC, Mehta S, Girard TD, Ranzani OT, Hammond N, Devlin JW, Shehabi Y, Pandharipande P, Ostermann M","Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE","Journal Article","2022-07-01","Intensive care medicine [Intensive Care Med] 2022 Jul; Vol. 48 (7), pp. 801-810. Date of Electronic Publication: 2022 May 19.","English","1432-1238","Anesthesia* , Dexmedetomidine*\/therapeutic use, Adult ; Humans ; Hypnotics and Sedatives\/therapeutic use ; Intensive Care Units ; Respiration, Artificial\/methods","Adult, Humans, Hypnotics and Sedatives therapeutic use, Intensive Care Units, Respiration, Artificial methods, Anesthesia, Dexmedetomidine therapeutic use","Intensive care medicine","48"]
Description
Purpose: The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM‑RPG) was to formulate evidence‑based guidance for the use of dexmedetomidine for sedation in invasively mechanically ventilated adults in the intensive care unit (ICU).<br />Methods: We adhered to the methodology for trustworthy clinical practice guidelines, including use of the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the certainty of evidence, and the Evidence-to-Decision framework to generate recommendations. The guideline panel comprised 28 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. Through teleconferences and web‑based discussions, the panel provided input on the balance and magnitude of the desirable and undesirable effects, the certainty of evidence, patients' values and preferences, costs and resources, feasibility, acceptability, and research priorities.<br />Results: The ICM‑RPG panel issued one weak recommendation (suggestion) based on overall moderate certainty of evidence: "In invasively mechanically ventilated adult ICU patients, we suggest using dexmedetomidine over other sedative agents, if the desirable effects including a reduction in delirium are valued over the undesirable effects including an increase in hypotension and bradycardia".<br />Conclusion: This ICM-RPG provides updated evidence-based guidance on the use of dexmedetomidine for sedation in mechanically ventilated adults, and outlines uncertainties and research priorities.<br /> (© 2022. Springer-Verlag GmbH Germany, part of Springer Nature.)
Published Date