2018 update of the APLAR recommendations for treatment of rheumatoid arthritis.
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Clinical Guidelines
Authored By
Lau CS, Chia F, Dans L, Harrison A, Hsieh TY, Jain R, Jung SM, Kishimoto M, Kumar A, Leong KP, Li Z, Lichauco JJ, Louthrenoo W, Luo SF, Mu R, Nash P, Ng CT, Suryana B, Wijaya LK, Yeap SS
Authored On
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Rheumatology
Orthopedic
Internal/Family Medicine
Speciality
Orthopedic
Rheumatology
Internal/Family Medicine
Book Detail
volume
22
ISSN
1756-185X
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{"article_title":"2018 update of the APLAR recommendations for treatment of rheumatoid arthritis.","author":"Lau CS, Chia F, Dans L, Harrison A, Hsieh TY, Jain R, Jung SM, Kishimoto M, Kumar A, Leong KP, Li Z, Lichauco JJ, Louthrenoo W, Luo SF, Mu R, Nash P, Ng CT, Suryana B, Wijaya LK, Yeap SS","journal_title":"International journal of rheumatic diseases","issn":"1756-185X","isbn":"","publication_date":"2018 Aug 01","volume":"22","issue":"3","first_page":"357","page_count":"","accession_number":"30809944","doi":"10.1111\/1756-185X.13513","publisher":"Wiley on behalf of the Asia Pacific League of Associations for Rheumatology","doctype":"Consensus Development Conference","subjects":"Asia; Antirheumatic Agents therapeutic use; Arthritis, Rheumatoid drug therapy; Rheumatology standards; Antirheumatic Agents adverse effects; Arthritis, Rheumatoid diagnosis; Arthritis, Rheumatoid epidemiology; Arthritis, Rheumatoid immunology; Asia epidemiology; Consensus; Delphi Technique; Evidence-Based Medicine standards; Humans; Patient Safety; Risk Assessment; Risk Factors; Treatment Outcome","interest_area":["Rheumatology"," Orthopedic"," Internal Medicine"],"abstract":"Aim: To update recommendations based on current best evidence concerning the treatment of rheumatoid arthritis (RA), focusing particularly on the role of targeted therapies, to inform clinicians on new developments that will impact their current practice. Materials and Methods: A search of relevant literature from 2014 to 2016 concerning targeted therapies in RA was conducted. The RA Update Working Group evaluated the evidence and proposed updated recommendations using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach, to describe the quality of evidence and strength of recommendations. Recommendations were finalized through consensus using the Delphi technique. Results: This update provides 16 RA treatment recommendations based on current best evidence and expert clinical opinion. Recommendations 1-3 deal with the use of conventional synthetic disease-modifying antirheumatic drugs. The next three recommendations (4-6) cover the need for screening and management of infections and comorbid conditions prior to starting targeted therapy, while the following seven recommendations focus on use of these agents. We address choice of targeted therapy, switch, tapering and discontinuation. The last three recommendations elaborate on targeted therapy for RA in special situations such as pregnancy, cancer, and major surgery. Conclusion: Rheumatoid arthritis remains a significant health problem in the Asia-Pacific region. Patients with RA can benefit from the availability of effective targeted therapies, and these updated recommendations provide clinicians with guidance on their use. \u00a9 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=30809944&authtype=shib&custid=ns346513&group=main&profile=eds","isPdfLink":true,"isSAML":false,"additionalInfo":{"Authored_By":"Lau CS, Chia F, Dans L, Harrison A, Hsieh TY, Jain R, Jung SM, Kishimoto M, Kumar A, Leong KP, Li Z, Lichauco JJ, Louthrenoo W, Luo SF, Mu R, Nash P, Ng CT, Suryana B, Wijaya LK, Yeap SS","Journal_Info":"Publisher: Wiley on behalf of the Asia Pacific League of Associations for Rheumatology Country of Publication: England NLM ID: 101474930 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-185X (Electronic) Linking ISSN: 17561841 NLM ISO Abbreviation: Int J Rheum Dis","Publication_Type":"Consensus Development Conference; Journal Article; Practice Guideline","Published_Date":"2019-03-01","Source":"International journal of rheumatic diseases [Int J Rheum Dis] 2019 Mar; Vol. 22 (3), pp. 357-375. Date of Electronic Publication: 2019 Feb 27.","Languages":"English","Electronic_ISSN":"1756-185X","MeSH_Terms":"Antirheumatic Agents\/*therapeutic use , Arthritis, Rheumatoid\/*drug therapy , Rheumatology\/*standards, Antirheumatic Agents\/adverse effects ; Arthritis, Rheumatoid\/diagnosis ; Arthritis, Rheumatoid\/epidemiology ; Arthritis, Rheumatoid\/immunology ; Asia\/epidemiology ; Consensus ; Delphi Technique ; Evidence-Based Medicine\/standards ; Humans ; Patient Safety ; Risk Assessment ; Risk Factors ; Treatment Outcome","Subjects":"Antirheumatic Agents adverse effects, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid epidemiology, Arthritis, Rheumatoid immunology, Asia epidemiology, Consensus, Delphi Technique, Evidence-Based Medicine standards, Humans, Patient Safety, Risk Assessment, Risk Factors, Treatment Outcome, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid drug therapy, Rheumatology standards","Title_Abbreviations":"International journal of rheumatic diseases","Volume":"22"},"header":{"DbId":"mdl","DbLabel":"MEDLINE Ultimate","An":"30809944","RelevancyScore":"822","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"822.281799316406"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=30809944&authtype=shib&custid=ns346513&group=main&profile=eds","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=30809944&authtype=shib&custid=ns346513&group=main&profile=eds"}
