Biodegradation of the Pesticide Fenamiphos by Ten Different Species of Green Algae and Cyanobacteria.
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Clinical Guidelines
Authored By
Cáceres, Tanya P., Megharaj, Mallavarapu, Naidu, Ravi
Authored On
Interests
Urology & Nephrology
Internal/Family Medicine
Emergency Medicine
Speciality
Emergency Medicine
Urology & Nephrology
Internal/Family Medicine
Book Detail
volume
57
ISSN
03438651
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{"article_title":"[Practice guideline for the treatment of familial amyloid polyneuropathy].","author":"Carretero M, S\u00e1ez MS, Posadas-Mart\u00ednez ML, Aguirre MA, Sorroche P, Negro A, Calandra CR, Salutto V, Lautre A, Conti E, Le\u00f3n-Cejas L, Reisin R, Nucifora EM, Rugiero M","journal_title":"Medicina","issn":"1669-9106","isbn":"","publication_date":"2020 Feb 07","volume":"82","issue":"2","first_page":"262","page_count":"","accession_number":"35417391","doi":"","publisher":"Fundacio\u0301n Revista Medicina (Buenos Aires)","doctype":"Practice Guideline","subjects":"Amyloid Neuropathies, Familial drug therapy; Benzoxazoles therapeutic use; Humans; Prealbumin therapeutic use; Quality of Life; Treatment Outcome","interest_area":["Urology & Nephrology"," Internal Medicine"," Emergency Medicine"],"abstract":"This clinical practice guideline for the treatment of familial amyloid polyneuropathy is based on the best available evidence of clinical effectiveness. A list of questions was generated with a PICO format focused on the effectiveness and safety of the treatment of familial amyloid polyneuropathy. The search was carried out in PubMed, Cochrane and Epistemonikos. The levels of evidence and grades of recommendation were based on the GRADE system. Recommendations were graded according to their direction and their strength and were evaluated with the GLIA tool for their implementation. In patients with familial amyloid polyneuropathy and stage I and II neuropathy, it is suggested: inotersen 300 mg subcutaneous weekly or patisir\u00e1n 0.3 mg\/kg intravenously once every 3 weeks, since they probably stabilize or slow the progression of neuropathy and worsening quality of life (moderate quality of evidence; strength of recommendation weak). In patients with familial amyloid polyneuropathy and stage I neuropathy, treatment with tafamidis 20 mg orally, once a day, is suggested, as it could slow the progression of neuropathy and worsen quality of life (low quality of evidence; strength of recommendation weak). In patients with familial amyloid polyneuropathy and symptomatic neuropathy and in the absence of other treatments with approved efficacy, treatment with oral diflunisal 250 mg twice daily is suggested, as it could prevent the progression of neuropathy (quality evidence low; strength of recommendation weak).","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=35417391&authtype=shib&custid=ns346513&group=main&profile=eds","isPdfLink":true,"isSAML":false,"additionalInfo":{"Authored_By":"C\u00e1ceres, Tanya P., Megharaj, Mallavarapu, Naidu, Ravi","Published_Date":"2008-12-01","Source":"Current Microbiology; Dec2008, Vol. 57 Issue 6, p643-646, 4p, 3 Charts","Languages":"English","Subjects":"BIODEGRADATION, CHEMICAL decomposition, PESTICIDES, GREEN algae, CYANOBACTERIA, ORGANOPHOSPHORUS compounds, PHYSIOLOGICAL oxidation, BIOREMEDIATION, ENVIRONMENTAL remediation, METABOLIC detoxification","Title_Abbreviations":"Current Microbiology","Volume":"57"},"header":{"DbId":"edb","DbLabel":"Complementary Index","An":"35417391","RelevancyScore":"833","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"833.215148925781"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=edb&AN=35417391&authtype=shib&custid=ns346513&group=main&profile=eds","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=edb&AN=35417391&authtype=shib&custid=ns346513&group=main&profile=eds"}
The degradation of an organophosphorus pesticide, fenamiphos, by different species of five green algae and five cyanobacteria was studied. All the species tested were able to transform fenamiphos to its primary oxidation product, fenamiphos sulfoxide (FSO), while the majority of these cultures were able to hydrolyze FSO to fenamiphos sulfoxide phenol (FSOP). Fenamiphos sulfone phenol, FSOP, and FSO were detected in the culture extracts of these algae and cyanobacteria. This is the first report on the biodegradation of a toxic pesticide, fenamiphos, by cyanobacteria. The ability of these algae and cyanobacteria to detoxify fenamiphos can be gainfully used in bioremediation of this pesticide and its toxic metabolites. [ABSTRACT FROM AUTHOR]