Real-World Effectiveness of Amlodipine in Hypertensive Patients in India

Amlodipine’s effectiveness for hypertension is well documented in trials, but real-world data in India remains limited. A retrospective analysis of 462 Indian patients with essential hypertension showed that amlodipine, whether used alone or with one other antihypertensive drug (AHD), significantly reduced systolic and diastolic blood pressure across age groups. Monotherapy reduced systolic BP by an average of 12.1 mmHg and diastolic BP by 7.5 mmHg, while combination therapy led to greater reductions of 17.8 mmHg systolic and 9.5 mmHg diastolic. Treatment goals were reached by 31.4% (SBP) and 42.9% (DBP) of monotherapy patients, and 38.9% (SBP) and 51.8% (DBP) of combination therapy patients. Similar significant BP reductions were observed in both younger (≤45 years) and older (≥65 years) patients. These findings support the real-world effectiveness of amlodipine in managing mild to moderate hypertension in Indian clinical practice.