Description
A recent study evaluated the safety and effectiveness of early antibiotic de-escalation in patients hospitalized with community-acquired pneumococcal pneumonia (CAPP). In a retrospective analysis of 1,410 CAPP cases, de-escalation to narrow-spectrum antibiotics within 72 hours was performed in 166 patients and was associated with a significantly shorter hospital stay without increasing 30-day mortality or adverse outcomes. These benefits remained consistent even in severely ill, clinically unstable, or bacteraemic patients. The study supports the safe use of de-escalation, addressing the previously limited evidence in this patient group.